12/30/2023 0 Comments Tcr sequenceEstimation of effective interresidue contact energies from protein crystal structures: quasi-chemical approximation. How the thymus designs antigen-specific and self-tolerant T cell receptor sequences. Cysteine and hydrophobic residues in CDR3 serve as distinct T-cell self-reactivity indices. Developmental plasticity of T H17 and T reg cells. VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. McPAS-TCR: a manually curated catalogue of pathology-associated T cell receptor sequences. Tickotsky, N., Sagiv, T., Prilusky, J., Shifrut, E. High frequency of shared clonotypes in human T cell receptor repertoires. Helios + and Helios – T reg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires. An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR–MHC complex. Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics. L., Esser, U., Fazekas de St Groth, B., Reay, P. Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease. Efficient and precise single-cell reference atlas mapping with Symphony. Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR. Pathogenic conversion of Foxp3 + T cells into T H17 cells in autoimmune arthritis. Homeostatic maintenance of natural Foxp3 +CD25 +CD4 + regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota. Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Clonal replacement of tumor-specific T cells following PD-1 blockade. Single-cell map of diverse immune phenotypes in the breast tumor microenvironment. Hydrophobic CDR3 residues promote the development of self-reactive T cells. Sequence variability analysis of human class I and class II MHC molecules: functional and structural correlates of amino acid polymorphisms. Genetic variation in MHC proteins is associated with T cell receptor expression biases. Good guys gone bad: exT reg cells promote autoimmune arthritis. Cross-reactive public TCR sequences undergo positive selection in the human thymic repertoire. A cell atlas of human thymic development defines T cell repertoire formation. T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes. Gomez-Tourino, I., Kamra, Y., Baptista, R., Lorenc, A. Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes. Antigen receptor repertoire profiling from RNA-seq data. ![]() Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis. T cell receptor signalling in the control of regulatory T cell differentiation and function. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for T reg cell development. T cell receptor signal strength in T reg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. Thymic selection and lineage commitment of CD4 +Foxp3 + regulatory T lymphocytes. Antigen presentation in the thymus for positive selection and central tolerance induction. Klein, L., Hinterberger, M., Wirnsberger, G. The Goldilocks conditions applied to T cell development. ![]() Thymic selection of CD4 +CD25 + regulatory T cells induced by an agonist self-peptide. ![]() These analyses revealed that hydrophobicity in the third complementarity-determining region (CDR3β) of the TCR promotes reactivity to self-peptides, while TCR variable gene ( TRBV gene) usage shapes the TCR’s general propensity for human MHC class II-restricted activation. To elucidate drivers of these predictive TCR features, we then examined the two elements of the T reg TCR ligand separately: the self-peptide and the human MHC class II molecule. When applied to the tumor microenvironment, TiRP scoring helped to explain why only some T cell clones maintained the conventional T cell (T conv) phenotype through expansion. From these results, we developed a scoring system to quantify TCR-intrinsic regulatory potential (TiRP). Using TCRβ sequences from flow-sorted human cells, we identified TCR features that promote regulatory T cell (T reg) fate. T cells acquire a regulatory phenotype when their T cell antigen receptors (TCRs) experience an intermediate- to high-affinity interaction with a self-peptide presented via the major histocompatibility complex (MHC).
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